The Guo Laboratory studies the genetic basis of cardiovascular disease, using human induced pluripotent stem cells, genome editing, and studies of heart development to understand how genetic variation causes disease.
Monogenic CVDs
Deciphering pathogenic variants, including variants of uncertain significance, in monogenic cardiovascular diseases using CRISPR-edited induced pluripotent stem cells (iPSCs).
Representative publications:
- Guo HC et al., Trends in Genetics (2021). PMID 34509299
- Belbachir et al., European Heart Journal (2019). PMID 31114854
Polygenic CVDs
Polygenic cardiovascular disease risk, including ALDH2- and SGLT2 inhibitor-related endothelial dysfunction.
Representative publications:
- Guo HC et al., Science Translational Medicine (2023). PMID 36696485
Congenital Heart Disease
The genetics of congenital heart disease, including hypoplastic left heart syndrome.
Representative publications:
- Wang et al., Cell Systems (2022). PMID 36167075
- Guo HC et al., Stem Cell Reports (2019). PMID 30827876
- Lee et al., Cell Stem Cell (2018). PMID 29499155
Endogenous Retroviruses
Endogenous retroviruses in heart development and disease, including the long noncoding RNA BANCR.
Representative publications:
- Wilson KD et al., Developmental Cell (2020). PMID 32763147